Altered Expression of Cell Cycle and Apoptotic Proteins in Human Liver Pathologies

Τhe expression of cell cycle (P53, Ki-67, P21, and P27) and apoptotic proteins (BCL-2 and BAX) was investigated by immunohistochemistry in paraffin-embedded formalin-fixed tissues of normal and pathologic liver. An increased frequency of expression of P21 in cirrhosis and hepatocellular carcinoma (H...

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Veröffentlicht in:	Anticancer research 2010-11, Vol.30 (11), p.4493-4501
Hauptverfasser:	MITSELOU, Antigony, KARAPIPERIDES, Damianos, NESSERIS, Ioannis, VOUGIOUKLAKIS, Theodoros, AGNANTIS, Niki J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Apoptosis bcl-2-Associated X Protein - metabolism Biological and medical sciences Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Cycle Proteins - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Fatty Liver - metabolism Fatty Liver - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Ki-67 Antigen - metabolism Liver - metabolism Liver - pathology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Proto-Oncogene Proteins c-bcl-2 - metabolism Tumor Suppressor Protein p53 - metabolism Tumors
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Zusammenfassung:	Τhe expression of cell cycle (P53, Ki-67, P21, and P27) and apoptotic proteins (BCL-2 and BAX) was investigated by immunohistochemistry in paraffin-embedded formalin-fixed tissues of normal and pathologic liver. An increased frequency of expression of P21 in cirrhosis and hepatocellular carcinoma (HCC) (p=0.003 and p=0.001 respectively) was found; P27 protein expression was more frequent in hepatitis (p=0.001) and HCC (p=0.003) when compared with normal tissue. BCL-2 protein was markedly more frequent in steatohepatitis (p
ISSN:	0250-7005 1791-7530