Stratification of the risk of serious allergic cutaneous reactions with therapeutic management of trigeminal neuralgia

Abstract Patients with the HLA-B*1502 allele have a high risk of serious allergic cutaneous reactions from antiepileptic drugs used in the management of trigeminal neuralgia. Awareness of this uncommon but potentially fatal reaction will help to avoid the use of these drugs in patients from racial g...

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Veröffentlicht in:	British journal of oral & maxillofacial surgery 2011-04, Vol.49 (3), p.235-236
Hauptverfasser:	Shakib, Kaveh, Sinanan, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - adverse effects Asian Continental Ancestry Group - genetics Biological and medical sciences Carbamazepine Carbamazepine - adverse effects China Dentistry Drug Hypersensitivity - ethnology Drug Hypersensitivity - genetics Drug reaction Gene Frequency HLA-B Antigens - genetics HLA-B15 Antigen Humans Medical sciences Otorhinolaryngology. Stomatology Risk Assessment Stevens-Johnson Syndrome - chemically induced Stevens-Johnson Syndrome - ethnology Stevens-Johnson Syndrome - etiology Stevens-Johnson Syndrome - genetics Stevens–Johnson syndrome Surgery Toxic epidermal necrolysis Trigeminal Neuralgia - drug therapy
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Zusammenfassung:	Abstract Patients with the HLA-B*1502 allele have a high risk of serious allergic cutaneous reactions from antiepileptic drugs used in the management of trigeminal neuralgia. Awareness of this uncommon but potentially fatal reaction will help to avoid the use of these drugs in patients from racial groups at high risk.
ISSN:	0266-4356 1532-1940
DOI:	10.1016/j.bjoms.2010.03.007