Facile Ring-Opening of Azabicyclic [3.1.0]- and [4.1.0]Aminocyclopropanes to Afford 3-Piperidinone and 3-Azepinone

Facile Ring-Opening of Azabicyclic [3.1.0]- and [4.1.0]Aminocyclopropanes to Afford 3-Piperidinone and 3-Azepinone

Azabicyclic [3.1.0] and [4.1.0] Kulinkovich products underwent a facile reduction/fragmentation to afford a variety of 3-piperidinones and 3-azepinones, respectively, in the presence of catalytic palladium on carbon and formic acid in an atmosphere of hydrogen.

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Veröffentlicht in:Organic letters 2011-03, Vol.13 (5), p.1083-1085
Hauptverfasser: Lee, Jisun, Berritt, Simon, Prier, Christopher K, Joullié, Madeleine M
Format: Artikel
Sprache:eng
Schlagworte:
Azabicyclo Compounds - chemistry
Azepines - chemical synthesis
Azepines - chemistry
Carbon - chemistry
Catalysis
Combinatorial Chemistry Techniques
Cyclopropanes - chemistry
Formates - chemistry
Hydrogen - chemistry
Molecular Structure
Palladium - chemistry
Piperidines - chemical synthesis
Piperidines - chemistry
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Zusammenfassung:Azabicyclic [3.1.0] and [4.1.0] Kulinkovich products underwent a facile reduction/fragmentation to afford a variety of 3-piperidinones and 3-azepinones, respectively, in the presence of catalytic palladium on carbon and formic acid in an atmosphere of hydrogen.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol103105q