Transmission of integrase strand-transfer inhibitor multidrug-resistant HIV-1: case report and response to raltegravir-containing antiretroviral therapy

We report the case of an integrase strand-transfer inhibitor (INI)-resistant and four-drug-class-resistant HIV-1 variant infecting an antiretroviral therapy-naive man. The virus harboured INI drug resistance substitutions (Q148H and G140S) along with multiple reverse transcriptase and protease inhib...

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Veröffentlicht in:	Antiviral therapy 2011-01, Vol.16 (2), p.253-256
Hauptverfasser:	YOUNG, Benjamin, FRANSEN, Signe, GREENBERG, Kenneth S, THOMAS, Amy, MARTENS, Sharon, ST CLAIR, Marty, PETROPOULOS, Christos J, HA, Belinda
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Drug Resistance, Multiple, Viral - genetics Genotype HIV Infections - drug therapy HIV Infections - transmission HIV Infections - virology HIV Integrase Inhibitors - pharmacology HIV Protease Inhibitors - pharmacology HIV-1 - drug effects HIV-1 - genetics Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Microbial Sensitivity Tests Middle Aged Mutation Pharmacology. Drug treatments Pyrrolidinones - pharmacology Raltegravir Potassium Reverse Transcriptase Inhibitors - pharmacology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Beschreibung
Zusammenfassung:	We report the case of an integrase strand-transfer inhibitor (INI)-resistant and four-drug-class-resistant HIV-1 variant infecting an antiretroviral therapy-naive man. The virus harboured INI drug resistance substitutions (Q148H and G140S) along with multiple reverse transcriptase and protease inhibitor resistance mutations. This case illustrates an emerging need to consider the possibility of acquired INI resistance among newly diagnosed treatment-naive individuals harbouring multidrug-resistant HIV-1.
ISSN:	1359-6535 2040-2058
DOI:	10.3851/IMP1748