Interaction between antiretroviral drugs and acenocoumarol

The authors report a case of an HIV type-1-infected patient concomitantly using highly active antiretroviral therapy and acenocoumarol anticoagulant for secondary prevention of recurrent venous thromboembolism. This is the first report of a possible drug interaction between efavirenz and atazanavir/...

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Veröffentlicht in:	Antiviral therapy 2011-01, Vol.16 (2), p.249-252
Hauptverfasser:	VVELZEN, Marieke Eb, VAN DEN BERK, Guido El, HAMERS, Raph L, BURGER, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acenocoumarol - therapeutic use Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Anticoagulants - therapeutic use Antiviral agents Atazanavir Sulfate Benzoxazines - therapeutic use Biological and medical sciences Drug Interactions Drug Therapy, Combination HIV Infections - complications HIV Infections - drug therapy HIV Infections - virology Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Middle Aged Oligopeptides - pharmacokinetics Oligopeptides - therapeutic use Pharmacology. Drug treatments Pyridines - pharmacokinetics Pyridines - therapeutic use Pyrrolidinones - pharmacokinetics Pyrrolidinones - therapeutic use Raltegravir Potassium Reverse Transcriptase Inhibitors - therapeutic use Ritonavir - pharmacokinetics Ritonavir - therapeutic use Venous Thrombosis - complications Venous Thrombosis - drug therapy Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Beschreibung
Zusammenfassung:	The authors report a case of an HIV type-1-infected patient concomitantly using highly active antiretroviral therapy and acenocoumarol anticoagulant for secondary prevention of recurrent venous thromboembolism. This is the first report of a possible drug interaction between efavirenz and atazanavir/ritonavir with acenocoumarol and also of the uncomplicated concurrent use of raltegravir with acenocoumarol.
ISSN:	1359-6535 2040-2058
DOI:	10.3851/IMP1714