DNMT3A mutations in acute myeloid leukemia

New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis rema...

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Veröffentlicht in:	Nature genetics 2011-03, Vol.43 (4), p.289-290
Hauptverfasser:	Shah, Mrinal Y, Licht, Jonathan D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/144/68 631/208/737 692/699/67/1990/283/1897 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Bone marrow Cancer Research Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation Epigenesis, Genetic Gene Function Genetics Hematopoiesis - genetics Human Genetics Humans Leukemia Leukemia, Myeloid, Acute - enzymology Leukemia, Myeloid, Acute - genetics Models, Genetic Mutation news-and-views Proteins
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Beschreibung
Zusammenfassung:	New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng0411-289