CALHM1 variant is not associated with Alzheimer's disease among Asians

Abstract In a case control study involving 484 study subjects, we showed that the CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. Logistic regression analysis did not reveal any interaction between ApoE4 allele...

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Veröffentlicht in:	Neurobiology of aging 2011-03, Vol.32 (3), p.546.e11-546.e12
Hauptverfasser:	Tan, E.K, Ho, P, Cheng, S.Y, Yih, Yuen, Li, H.H, Fook-Chong, S, Lee, W.L, Zhao, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E4 - genetics Asia - epidemiology Asia - ethnology Calcium Channels - genetics Case-Control Studies Female Gene Gene Frequency Genome-Wide Association Study - methods Genotype Humans Internal Medicine Logistic Models Male Membrane Glycoproteins - genetics Middle Aged Neurology Patients Polymorphism, Single Nucleotide - genetics
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creator	Tan, E.K Ho, P Cheng, S.Y Yih, Yuen Li, H.H Fook-Chong, S Lee, W.L Zhao, Yi
description	Abstract In a case control study involving 484 study subjects, we showed that the CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. Logistic regression analysis did not reveal any interaction between ApoE4 allele and CALHM1 allele.
doi_str_mv	10.1016/j.neurobiolaging.2009.05.008
format	Article
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-43a8bc32a8a7c54f2612d7effc3c9dbeb13fe86b89f9a8cabb0f81e879c05a283</citedby><cites>FETCH-LOGICAL-c440t-43a8bc32a8a7c54f2612d7effc3c9dbeb13fe86b89f9a8cabb0f81e879c05a283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0197458009001717$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19545933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, E.K</creatorcontrib><creatorcontrib>Ho, P</creatorcontrib><creatorcontrib>Cheng, S.Y</creatorcontrib><creatorcontrib>Yih, Yuen</creatorcontrib><creatorcontrib>Li, H.H</creatorcontrib><creatorcontrib>Fook-Chong, S</creatorcontrib><creatorcontrib>Lee, W.L</creatorcontrib><creatorcontrib>Zhao, Yi</creatorcontrib><title>CALHM1 variant is not associated with Alzheimer's disease among Asians</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Abstract In a case control study involving 484 study subjects, we showed that the CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. Logistic regression analysis did not reveal any interaction between ApoE4 allele and CALHM1 allele.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Asia - epidemiology</subject><subject>Asia - ethnology</subject><subject>Calcium Channels - genetics</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gene</subject><subject>Gene Frequency</subject><subject>Genome-Wide Association Study - methods</subject><subject>Genotype</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Patients</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EotvCX0A-IPWUME7itS0hpFXF0kpFHICz5TiTrZfELp6kVfn1ZLUrIThxmsv7oXlext4KKAWI9bt9GXHOqQ1pcLsQd2UFYEqQJYB-xlZCSl2IxqjnbAXCqKKRGs7YOdEeAFSj1i_ZmTCykaauV2x7tbm9_iz4g8vBxYkH4jFN3BElH9yEHX8M0x3fDL_uMIyYL4l3gdARcjemuOMbWnz0ir3o3UD4-nQv2Pftx29X18Xtl083S0Xhmwamoqmdbn1dOe2Ul01frUXVKex7X3vTtdiKuke9brXpjdPetS30WqBWxoN0la4v2OUx9z6nnzPSZMdAHofBRUwzWS0NSFOBWpTvj0qfE1HG3t7nMLr8ZAXYA0i7t3-DtAeQFqRdQC72N6eiuR2x-2M-kVsE26MAl3cfAmZLPmD02IWMfrJdCv_b9OGfID-EGLwbfuAT0j7NOS5IrbBUWbBfD6MeNgUDIJRQ9W9Qk6JY</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Tan, E.K</creator><creator>Ho, P</creator><creator>Cheng, S.Y</creator><creator>Yih, Yuen</creator><creator>Li, H.H</creator><creator>Fook-Chong, S</creator><creator>Lee, W.L</creator><creator>Zhao, Yi</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>CALHM1 variant is not associated with Alzheimer's disease among Asians</title><author>Tan, E.K ; Ho, P ; Cheng, S.Y ; Yih, Yuen ; Li, H.H ; Fook-Chong, S ; Lee, W.L ; Zhao, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-43a8bc32a8a7c54f2612d7effc3c9dbeb13fe86b89f9a8cabb0f81e879c05a283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer's disease</topic><topic>Apolipoprotein E4 - genetics</topic><topic>Asia - epidemiology</topic><topic>Asia - ethnology</topic><topic>Calcium Channels - genetics</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gene</topic><topic>Gene Frequency</topic><topic>Genome-Wide Association Study - methods</topic><topic>Genotype</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Patients</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, E.K</creatorcontrib><creatorcontrib>Ho, P</creatorcontrib><creatorcontrib>Cheng, S.Y</creatorcontrib><creatorcontrib>Yih, Yuen</creatorcontrib><creatorcontrib>Li, H.H</creatorcontrib><creatorcontrib>Fook-Chong, S</creatorcontrib><creatorcontrib>Lee, W.L</creatorcontrib><creatorcontrib>Zhao, Yi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, E.K</au><au>Ho, P</au><au>Cheng, S.Y</au><au>Yih, Yuen</au><au>Li, H.H</au><au>Fook-Chong, S</au><au>Lee, W.L</au><au>Zhao, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CALHM1 variant is not associated with Alzheimer's disease among Asians</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>32</volume><issue>3</issue><spage>546.e11</spage><epage>546.e12</epage><pages>546.e11-546.e12</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><abstract>Abstract In a case control study involving 484 study subjects, we showed that the CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. Logistic regression analysis did not reveal any interaction between ApoE4 allele and CALHM1 allele.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19545933</pmid><doi>10.1016/j.neurobiolaging.2009.05.008</doi></addata></record>
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subjects	Adult Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E4 - genetics Asia - epidemiology Asia - ethnology Calcium Channels - genetics Case-Control Studies Female Gene Gene Frequency Genome-Wide Association Study - methods Genotype Humans Internal Medicine Logistic Models Male Membrane Glycoproteins - genetics Middle Aged Neurology Patients Polymorphism, Single Nucleotide - genetics
title	CALHM1 variant is not associated with Alzheimer's disease among Asians
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