CALHM1 variant is not associated with Alzheimer's disease among Asians

Abstract In a case control study involving 484 study subjects, we showed that the CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. Logistic regression analysis did not reveal any interaction between ApoE4 allele...

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Veröffentlicht in:	Neurobiology of aging 2011-03, Vol.32 (3), p.546.e11-546.e12
Hauptverfasser:	Tan, E.K, Ho, P, Cheng, S.Y, Yih, Yuen, Li, H.H, Fook-Chong, S, Lee, W.L, Zhao, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer's disease Apolipoprotein E4 - genetics Asia - epidemiology Asia - ethnology Calcium Channels - genetics Case-Control Studies Female Gene Gene Frequency Genome-Wide Association Study - methods Genotype Humans Internal Medicine Logistic Models Male Membrane Glycoproteins - genetics Middle Aged Neurology Patients Polymorphism, Single Nucleotide - genetics
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Zusammenfassung:	Abstract In a case control study involving 484 study subjects, we showed that the CALHM1 allele (13.5% vs 16.7%) and genotype frequency was not significantly different between Alzheimer's disease (AD) and controls. Logistic regression analysis did not reveal any interaction between ApoE4 allele and CALHM1 allele.
ISSN:	0197-4580 1558-1497
DOI:	10.1016/j.neurobiolaging.2009.05.008