Comprehensive Study of Alkaloids from Crinum asiaticum var. sinicum Assisted by HPLC-DAD-SPE-NMR

A comprehensive study of the alkaloids presentin the leaves of Crinum asiaticum var. sinicum, assisted by HPLC-SPE-NMR, led to the characterization of 21 compounds of similar polarity on an analytical scale. Thirteen of these were isolated for further structural confirmation. Seven are proved to be...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2011-03, Vol.74 (3), p.411-419
Hauptverfasser:	Chen, Chien-Kuang, Lin, Feng-Hsu, Tseng, Li-Hong, Jiang, Chia-Ling, Lee, Shoei-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Biological and medical sciences Chromatography, High Pressure Liquid Crinum - chemistry General pharmacology Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Leaves - chemistry Stereoisomerism
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Zusammenfassung:	A comprehensive study of the alkaloids presentin the leaves of Crinum asiaticum var. sinicum, assisted by HPLC-SPE-NMR, led to the characterization of 21 compounds of similar polarity on an analytical scale. Thirteen of these were isolated for further structural confirmation. Seven are proved to be new, namely, (+)-siculine (4), 1-epijosephinine (11), 7-methoxycrinamabine (10), 2-O-acetylcrinamabine (16), 3-O-acetyl-8-O-demethylmaritidine (17), 2-O-acetylbulbisine (18), and 1-O-acetylbulbisine (19). In addition, dihydrovittatine (6) and 8-O-demethyloxomaritidine (21) were isolated for the first time from Nature, although they have been prepared previously as synthetic products. Their structures were established by spectroscopic analysis.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np100819n