Iron-Catalyzed Aminolysis of β-Carbonyl 1,3-Dithianes: Synthesis of Stereodefined β-Enaminones and 3,4-Disubstituted Pyrazoles

Iron-Catalyzed Aminolysis of β-Carbonyl 1,3-Dithianes: Synthesis of Stereodefined β-Enaminones and 3,4-Disubstituted Pyrazoles

A novel iron-catalyzed aminolysis of β-carbonyl 1,3-dithianes with various amines including ammonia, primary and secondary amines, as well as hydrazine hydrate has been developed, leading to the synthesis of stereodefined β-enaminones and 3,4-disubstituted pyrazoles in good to high yields.

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Veröffentlicht in:Organic letters 2011-04, Vol.13 (7), p.1722-1725
Hauptverfasser: Wang, Yeming, Bi, Xihe, Li, Wei-Qi, Li, Dehua, Zhang, Qian, Liu, Qun, Ondon, Brim Stevy
Format: Artikel
Sprache:eng
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Zusammenfassung:A novel iron-catalyzed aminolysis of β-carbonyl 1,3-dithianes with various amines including ammonia, primary and secondary amines, as well as hydrazine hydrate has been developed, leading to the synthesis of stereodefined β-enaminones and 3,4-disubstituted pyrazoles in good to high yields.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol200246x