Stereoselective Direct Amine-Catalyzed Decarboxylative Aldol Addition

Stereoselective Direct Amine-Catalyzed Decarboxylative Aldol Addition

A stereoselective decarboxylative aldol addition of β- and α-keto acids in the presence of catalytic amounts of amines is described. By the optional deployment of chiral enolizable aldehydes an access to enantiopure configurative defined ketopentoses, ketohexoses, or ketoheptoses is given.

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Veröffentlicht in:Organic letters 2011-04, Vol.13 (7), p.1878-1880
Hauptverfasser: Rohr, Kerstin, Mahrwald, Rainer
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - chemistry
Amines - chemistry
Catalysis
Molecular Structure
Stereoisomerism
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Zusammenfassung:A stereoselective decarboxylative aldol addition of β- and α-keto acids in the presence of catalytic amounts of amines is described. By the optional deployment of chiral enolizable aldehydes an access to enantiopure configurative defined ketopentoses, ketohexoses, or ketoheptoses is given.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol200412r