Common variable immunodeficiency presenting as herpes simplex virus encephalitis

Based on these clinical and laboratory results, she was given a diagnosis of CVID and started on intravenous immunoglobulin (IVIG). Since beginning treatment, she has not experienced any infectious complications and has not required any form of antimicrobial treatment. CVID is characterized by decreased qualitative and quantitative immunoglobulin levels, resulting in infections, most often by bacterial pathogens.1 The frequent concurrence of defects in T-cell immunity also predisposes patients to disseminated viral infections, particularly with herpes viruses, and to systemic fungal infections.