Quality assessment of a placental perfusion protocol

Validation of in vitro test systems using the modular approach with steps addressing reliability and relevance is an important aim when developing in vitro tests in e.g. reproductive toxicology. The ex vivo human placental perfusion system may be used for such validation, here presenting the placent...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2010-08, Vol.30 (1), p.138-146
Hauptverfasser:	Mathiesen, Line, Mose, Tina, Mørck, Thit Juul, Nielsen, Jeanette Kolstrup Søgaard, Nielsen, Leif Kofoed, Maroun, Lisa Leth, Dziegiel, Morten Hanefeld, Larsen, Lise Grupe, Knudsen, Lisbeth Ehlert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Testing Alternatives Antipyrine Antipyrine - pharmacokinetics Caesarean section Equipment Design Female FITC-dextran Humans In Vitro Techniques Maternal-Fetal Exchange Modular validation approach Perfusion - instrumentation Perfusion - methods Perfusion - standards Placenta - metabolism Placental perfusion transport model Pregnancy Quality Control Reproduction - drug effects Success rate Toxicity Tests - instrumentation Toxicity Tests - methods Toxicity Tests - standards Vaginal birth
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