Controlled ovarian hyperstimulation for low responders in in vitro fertilization/intracytoplasmic sperm injection: a low-dose flare protocol

In this retrospective study of 652 anticipated low response women, the overall clinical outcomes (live birth rate and clinical pregnancy rate [PR]) of low-dose flare (LDF) protocol appeared lower than those of conventional down-regulation (DR) (LDF: 15.1% vs. DR: 20.6% and LDF: 10.3% vs. DR: 17.4%,...

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Veröffentlicht in:	Fertility and sterility 2011-04, Vol.95 (5), p.1809-1812
Hauptverfasser:	Datta, Adrija Kumar, M.R.C.O.G, Vitthala, Srisailesh, M.R.C.O.G, Tozer, Amanda, M.R.C.O.G, Zosmer, Ariel, Ph.D, Sabatini, Luca, M.R.C.O.G, Davis, Colin, F.R.C.O.G, Al-Shawaf, Talha, F.R.C.O.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Assisted reproduction technology Biological and medical sciences Birth control Birth Rate Dose-Response Relationship, Drug down-regulation Drug Administration Schedule Female Fertility Agents, Female - administration & dosage Fertilization in Vitro - methods Gynecology. Andrology. Obstetrics Humans ICSI Infertility, Female - therapy Internal Medicine intracytoplasmic sperm injection IVF low ovarian reserve low responder low-dose flare Male Medical sciences modified microdose flare Obstetrics and Gynecology Ovulation Induction - methods Pregnancy Pregnancy Rate Retrospective Studies Sperm Injections, Intracytoplasmic - methods Sterility. Assisted procreation Treatment Failure women
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Zusammenfassung:	In this retrospective study of 652 anticipated low response women, the overall clinical outcomes (live birth rate and clinical pregnancy rate [PR]) of low-dose flare (LDF) protocol appeared lower than those of conventional down-regulation (DR) (LDF: 15.1% vs. DR: 20.6% and LDF: 10.3% vs. DR: 17.4%, respectively). The findings that LDF protocol improved the clinical outcome in older women, or when LDF followed an unsuccessful IVF/intracytoplasmic sperm injection (ICSI) cycle with DR (LDF: 19.4% vs. DR: 9.76% and LDF: 13.9% vs. DR: 4.2% respectively), need further evaluation through randomized trials.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2010.11.049