Expression profiles of genes associated with viral entry in HCV-infected human liver

Recent studies have demonstrated that several cellular factors are involved in entry of hepatitis C virus (HCV) into host cells. Detailed gene expression profiles of these factors in HCV‐infected livers have not been reported for humans. Transcriptional levels of LDL receptor (LDLR), CD81, scavenger...

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Veröffentlicht in:	Journal of medical virology 2011-05, Vol.83 (5), p.921-927
Hauptverfasser:	Nakamuta, M., Fujino, T., Yada, R., Aoyagi, Y., Yasutake, K., Kohjima, M., Fukuizumi, K., Yoshimoto, T., Harada, N., Yada, M., Kato, M., Kotoh, K., Taketomi, A., Maehara, Y., Nakashima, M., Enjoji, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antigens, CD - biosynthesis Biological and medical sciences CD81 Cholesterol, LDL - blood Claudin-1 Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Expression Regulation Genetics Hepacivirus - pathogenicity Hepacivirus - physiology Hepatitis C virus Hepatitis C, Chronic - pathology Hepatitis C, Chronic - virology Host-Pathogen Interactions Human viral diseases Humans Immunohistochemistry Infectious diseases LDL receptor Liver - virology Male Medical sciences Membrane Proteins - biosynthesis Microbiology Middle Aged Miscellaneous Occludin Receptors, LDL - biosynthesis Reverse Transcriptase Polymerase Chain Reaction scavenger receptor class B type I Scavenger Receptors, Class B - biosynthesis Tetraspanin 28 Viral Core Proteins - blood Viral diseases Virology Virus Internalization
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Zusammenfassung:	Recent studies have demonstrated that several cellular factors are involved in entry of hepatitis C virus (HCV) into host cells. Detailed gene expression profiles of these factors in HCV‐infected livers have not been reported for humans. Transcriptional levels of LDL receptor (LDLR), CD81, scavenger receptor class B type I (SR‐BI), claudin‐1, and occludin genes in liver samples from patients with chronic hepatitis C were investigated. Serum levels of LDL‐cholesterol (LDL‐C) and HCV core antigen were also evaluated, and expression of claudin‐1 and occludin were immunohistochemically analyzed. Compared with normal liver, transcription of LDLR and claudin‐1 genes was significantly suppressed (P
ISSN:	0146-6615 1096-9071
DOI:	10.1002/jmv.22042