Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus

Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus

Three in one: Verruculogen synthase FtmF is a key enzyme to diversify the fumitremorgin biosynthetic pathway in Aspergillus fumigatus: FtmF catalyzes not only endoperoxide bond formation of verruculogen but also the deprenylation and oxidation of fumitremorgin B to yield 12α,13α‐dihydroxyfumitremorg...

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2011-03, Vol.12 (5), p.711-714
Hauptverfasser: Kato, Naoki, Suzuki , Hirokazu, Takagi, Hiroshi, Uramoto, Masakazu, Takahashi, Shunji, Osada, Hiroyuki
Format: Artikel
Sprache:eng
Schlagworte:
Aspergillus fumigatus
Aspergillus fumigatus - enzymology
Aspergillus fumigatus - genetics
biosynthesis
dioxygenase
Dioxygenases - genetics
Dioxygenases - metabolism
endoperoxide bond
Genes, Fungal
Indoles - metabolism
natural products
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Zusammenfassung:Three in one: Verruculogen synthase FtmF is a key enzyme to diversify the fumitremorgin biosynthetic pathway in Aspergillus fumigatus: FtmF catalyzes not only endoperoxide bond formation of verruculogen but also the deprenylation and oxidation of fumitremorgin B to yield 12α,13α‐dihydroxyfumitremorgin C and 13‐oxoverruculogen, respectively.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201000562