STD and trNOESY NMR Study of Receptor-Ligand Interactions in Living Cancer Cells
Integrin antagonists: Saturation transfer difference (STD) and transferred NOE provided useful information on membrane‐bound receptor–ligand interactions in living cells in which the integrin αvβ3 is highly expressed. The epitopes of two cyclic RGD mimics were identified by STD. The different activi...
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| Veröffentlicht in: | Chembiochem : a European journal of chemical biology 2011-03, Vol.12 (5), p.695-699 |
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| container_title | Chembiochem : a European journal of chemical biology |
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| creator | Potenza, Donatella Vasile, Francesca Belvisi, Laura Civera, Monica Araldi, Elena M. V. |
| description | Integrin antagonists: Saturation transfer difference (STD) and transferred NOE provided useful information on membrane‐bound receptor–ligand interactions in living cells in which the integrin αvβ3 is highly expressed. The epitopes of two cyclic RGD mimics were identified by STD. The different activities of these compounds were interpreted in terms of different binding modes. The experimental evidence was confirmed by docking calculations. |
| doi_str_mv | 10.1002/cbic.201000756 |
| format | Article |
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The experimental evidence was confirmed by docking calculations.</description><identifier>ISSN: 1439-4227</identifier><identifier>EISSN: 1439-7633</identifier><identifier>DOI: 10.1002/cbic.201000756</identifier><identifier>PMID: 21404411</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Cell Line, Tumor ; Humans ; Integrin alpha Chains - chemistry ; Integrin alpha Chains - metabolism ; Integrin beta Chains - chemistry ; Integrin beta Chains - metabolism ; Ligands ; living cancer cells ; membrane proteins ; Models, Molecular ; molecular modeling ; Nuclear Magnetic Resonance, Biomolecular - methods ; Oligopeptides - metabolism ; Protein Binding ; protein-ligand interactions ; STD-NMR ; Urinary Bladder Neoplasms - metabolism</subject><ispartof>Chembiochem : a European journal of chemical biology, 2011-03, Vol.12 (5), p.695-699</ispartof><rights>Copyright © 2011 WILEY‐VCH Verlag GmbH & Co. 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| ispartof | Chembiochem : a European journal of chemical biology, 2011-03, Vol.12 (5), p.695-699 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Cell Line, Tumor Humans Integrin alpha Chains - chemistry Integrin alpha Chains - metabolism Integrin beta Chains - chemistry Integrin beta Chains - metabolism Ligands living cancer cells membrane proteins Models, Molecular molecular modeling Nuclear Magnetic Resonance, Biomolecular - methods Oligopeptides - metabolism Protein Binding protein-ligand interactions STD-NMR Urinary Bladder Neoplasms - metabolism |
| title | STD and trNOESY NMR Study of Receptor-Ligand Interactions in Living Cancer Cells |
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