Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide

Hyaluronan is a high-molecular mass component of pulmonary extracelluar matrix, and lung injury can generate a low-molecular mass hyaluronan (HA) fragment that functions as endogenous ligand to cell surface receptors CD44 and TLR4. This leads to activation of intracellular NF-κB signaling and proinf...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-12, Vol.185 (11), p.6891-6898
Hauptverfasser:	Li, Zhuowei, Potts, Erin N, Piantadosi, Claude A, Foster, W Michael, Hollingsworth, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - immunology Acute Lung Injury - pathology Administration, Inhalation Animals Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Cells, Cultured Dose-Response Relationship, Immunologic Hyaluronan Receptors - metabolism Hyaluronic Acid - biosynthesis Hyaluronic Acid - chemistry Hyaluronic Acid - toxicity Lipopolysaccharides - administration & dosage Lipopolysaccharides - chemistry Lipopolysaccharides - pharmacology Macrophages, Alveolar - drug effects Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Male Mice Mice, Inbred C57BL Molecular Weight Ozone - administration & dosage Ozone - chemistry Ozone - toxicity
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