Subtype prevalence, plasmid profiles and growing fluoroquinolone resistance in Shigella from Kolkata, India (2001-2007): a hospital‐based study

Objectives Shigellosis is a major public health problem, and increasing antimicrobial resistance has complicated its treatment. We report isolation frequency, plasmid profiles and antimicrobial resistance of Shigella subtypes in Kolkata, India, from a prospective hospital‐based study. Methods Fresh...

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Veröffentlicht in:	Tropical medicine & international health 2010-12, Vol.15 (12), p.1499-1507
Hauptverfasser:	Nandy, Suman, Mitra, Utpala, Rajendran, K, Dutta, Phalguni, Dutta, Shanta
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial agents antimicrobial resistance Biological and medical sciences Child, Preschool Diarrhea - microbiology DNA, Bacterial - genetics Drug resistance Drug Resistance, Bacterial Dysentery, Bacillary - drug therapy Dysentery, Bacillary - epidemiology Dysentery, Bacillary - microbiology Female fluoroquinolone Fluoroquinolones - pharmacology General aspects Humans India - epidemiology Infant Infant, Newborn Male Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments plasmid Plasmids - genetics Shigella Shigella - classification Shigella - drug effects Shigella - genetics Shigella - isolation & purification Shigellosis subtypes
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Zusammenfassung:	Objectives Shigellosis is a major public health problem, and increasing antimicrobial resistance has complicated its treatment. We report isolation frequency, plasmid profiles and antimicrobial resistance of Shigella subtypes in Kolkata, India, from a prospective hospital‐based study. Methods Fresh stool or rectal swabs were collected from children (25.0%) of FQ‐resistant S. flexneri 2a, and S. flexneri 3a in 2004, which restricted use of fluoroquinolones for treatment. A number of smaller plasmids (
ISSN:	1360-2276 1365-3156
DOI:	10.1111/j.1365-3156.2010.02656.x