A Highly Selective Pyrophosphate Sensor Based on ESIPT Turn-On in Water

A Highly Selective Pyrophosphate Sensor Based on ESIPT Turn-On in Water

Pyrophosphate (PPi) is a biologically important target. A binuclear system 3•2Zn is found to selectively recognize PPi, leading to a ratiometric fluorescent sensor at pH 7.4 in water. The binding event triggered a large fluorescence response (∼100 nm bathochromic shift) by turning on the excited sta...

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Veröffentlicht in:Organic letters 2011-03, Vol.13 (6), p.1362-1365
Hauptverfasser: Chen, Wei-Hua, Xing, Yu, Pang, Yi
Format: Artikel
Sprache:eng
Schlagworte:
Diphosphates - analysis
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Hydrogen-Ion Concentration
Protons
Spectrometry, Fluorescence - methods
Water - chemistry
Zinc - analysis
Zinc - chemistry
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Zusammenfassung:Pyrophosphate (PPi) is a biologically important target. A binuclear system 3•2Zn is found to selectively recognize PPi, leading to a ratiometric fluorescent sensor at pH 7.4 in water. The binding event triggered a large fluorescence response (∼100 nm bathochromic shift) by turning on the excited state intramolecular proton transfer (ESIPT). Detection of PPi released from a PCR experiment indicated that this new probe could be a useful tool in bioanalytical applications.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol200054w