Unique X-ray Sheet Structure of 1,8-Bis(imidazolium) Anthracene and Its Application as a Fluorescent Probe for DNA and DNase

A new imidazolium anthracene derivative 1 was synthesized, and its unique X-ray crystal structure was examined. In aqueous solutions, probe 1 exhibited a selective fluorescent quenching effect only with DNA among various anions including the nucleotides investigated. This probe was further applied t...

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Veröffentlicht in:	Organic letters 2011-03, Vol.13 (6), p.1314-1317
Hauptverfasser:	Kim, Ha Na, Lim, Jisoo, Lee, Han Na, Ryu, Ju-Woo, Kim, Min Jung, Lee, Joohee, Lee, Dong-Ung, Kim, Youngmee, Kim, Sung-Jin, Lee, Kap Duk, Lee, Hee-Seung, Yoon, Juyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracenes - chemical synthesis Anthracenes - chemistry Crystallography, X-Ray Deoxyribonucleases - analysis Deoxyribonucleases - metabolism DNA - analysis DNA - chemistry Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Imidazoles - chemical synthesis Imidazoles - chemistry Molecular Conformation Molecular Structure
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Beschreibung
Zusammenfassung:	A new imidazolium anthracene derivative 1 was synthesized, and its unique X-ray crystal structure was examined. In aqueous solutions, probe 1 exhibited a selective fluorescent quenching effect only with DNA among various anions including the nucleotides investigated. This probe was further applied to monitor the activity of DNase.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol103166q