Copper-Catalyzed Direct Benzylation or Allylation of 1,3-Azoles with N-Tosylhydrazones

Copper-Catalyzed Direct Benzylation or Allylation of 1,3-Azoles with N-Tosylhydrazones

Cu-Catalyzed cross-coupling of N-tosylhydrazones with 1,3-azoles leads to the direct C−H benzylation or allylation. Cu carbene migratory insertion is proposed to play the key role in this transformation.

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Veröffentlicht in:Journal of the American Chemical Society 2011-03, Vol.133 (10), p.3296-3299
Hauptverfasser: Zhao, Xia, Wu, Guojiao, Zhang, Yan, Wang, Jianbo
Format: Artikel
Sprache:eng
Schlagworte:
Azoles - chemistry
Catalysis
Copper - chemistry
Hydrazones - chemistry
Tosyl Compounds - chemistry
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Zusammenfassung:Cu-Catalyzed cross-coupling of N-tosylhydrazones with 1,3-azoles leads to the direct C−H benzylation or allylation. Cu carbene migratory insertion is proposed to play the key role in this transformation.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja111249p