Differential regulation of synaptic and extra-synaptic NMDA receptors

A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown-the decline of peak current with repeated, sustained agonist application. Here we report that calcium and tyrosine phosphorylation differentially regulate rundown of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2002-09, Vol.5 (9), p.833-834
Hauptverfasser:	Raymond, Lynn A, Li, Bo, Chen, Nansheng, Luo, Tao, Otsu, Yo, Murphy, Timothy H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine brief-communication Calcium - metabolism Calcium ions Calcium Signaling - drug effects Calcium Signaling - physiology Cell Membrane - drug effects Cell Membrane - metabolism Cells, Cultured Endocytosis - drug effects Endocytosis - physiology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Kinases Localization N-Methylaspartate - pharmacology Neural receptors Neural transmission Neurobiology Neurons Neurosciences Phosphoric Monoester Hydrolases - metabolism Physiological aspects Piperidines - pharmacology Protein Transport - drug effects Protein Transport - physiology Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Pyramidal Cells - cytology Pyramidal Cells - drug effects Pyramidal Cells - metabolism Rats Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism Synapses - drug effects Synapses - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown-the decline of peak current with repeated, sustained agonist application. Here we report that calcium and tyrosine phosphorylation differentially regulate rundown of synaptic versus extrasynaptic NMDAR-mediated current in rat hippocampal pyramidal neurons.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn912