Can changes in cortical excitability distinguish progressive from juvenile myoclonic epilepsy?

Summary Purpose: We used transcranial magnetic stimulation (TMS) to investigate whether there were any characteristic cortical excitability changes in progressive myoclonic epilepsy (PME) compared to juvenile myoclonic epilepsy (JME). Methods: Six patients with PME were studied. Motor threshold (M...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2010-10, Vol.51 (10), p.2084-2088
Hauptverfasser:	Badawy, Radwa A.B., Macdonell, Richard A.L., Jackson, Graeme D, Berkovic, Samuel F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticonvulsants - therapeutic use Biological and medical sciences Cerebral Cortex - physiopathology Chronic Disease Cortex Cortical excitability Diagnosis, Differential Drug Resistance Epilepsy Excitability Female g-Aminobutyric acid gamma-Aminobutyric Acid - physiology Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Interstimulus interval Juvenile myoclonic epilepsy Male Malformations of the nervous system Medical sciences Middle Aged Motor Cortex - physiopathology Myoclonic Epilepsies, Progressive - diagnosis Myoclonic Epilepsies, Progressive - drug therapy Myoclonic Epilepsies, Progressive - physiopathology Myoclonic Epilepsy, Juvenile - diagnosis Myoclonic Epilepsy, Juvenile - drug therapy Myoclonic Epilepsy, Juvenile - physiopathology Nervous system (semeiology, syndromes) Neurology paired-pulse stimulation Progressive myoclonic epilepsy Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods Transcranial Magnetic Stimulation - statistics & numerical data Unverricht-Lundborg Syndrome - diagnosis Unverricht-Lundborg Syndrome - physiopathology
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Zusammenfassung:	Summary Purpose: We used transcranial magnetic stimulation (TMS) to investigate whether there were any characteristic cortical excitability changes in progressive myoclonic epilepsy (PME) compared to juvenile myoclonic epilepsy (JME). Methods: Six patients with PME were studied. Motor threshold (MT) at rest and recovery curve analysis using paired‐pulse stimulation at a number of interstimulus intervals (ISIs) was determined. Results were compared to those of 9 patients with chronic refractory JME and 10 with chronic well‐controlled JME. Results: PME showed a marked increase in cortical excitability at all the long ISIs (p
ISSN:	0013-9580 1528-1167
DOI:	10.1111/j.1528-1167.2010.02557.x