Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans

Research highlights ▶ Three IL-1R A gene polymorphisms were associated with acute coronary syndrome. ▶ The functional effect of the RN.6/2C > G polymorphism was not observed. ▶ RN.4T > C polymorphism was associated with several cardiovascular risk factors. ▶ One risk and 3 protective haplotype...

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Veröffentlicht in:	Immunology letters 2010-10, Vol.133 (2), p.106-111
Hauptverfasser:	Fragoso, José Manuel, Delgadillo, Hilda, Llorente, Luis, Chuquiure, Eduardo, Juárez-Cedillo, Teresa, Vallejo, Maite, Lima, Guadalupe, Furuzawa-Carballeda, Janette, Peña-Duque, Marco Antonio, Martínez-Ríos, Marco Antonio, Vargas-Alarcón, Gilberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndrome Acute Coronary Syndrome - epidemiology Acute Coronary Syndrome - genetics Acute Coronary Syndrome - immunology Acute Coronary Syndrome - physiopathology Aged Allergy and Immunology Arteriosclerosis Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Genetic susceptibility Haplotypes Humans Hypertension Interleukin 1 Receptor Antagonist Protein - genetics Interleukin 1 Receptor Antagonist Protein - immunology Interleukin-1 Interleukin-1 - genetics Interleukin-1 - immunology Linkage Disequilibrium Male Mexico Middle Aged Myocardial Infarction Polymorphism, Genetic Polymorphisms Risk Factors
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Zusammenfassung:	Research highlights ▶ Three IL-1R A gene polymorphisms were associated with acute coronary syndrome. ▶ The functional effect of the RN.6/2C > G polymorphism was not observed. ▶ RN.4T > C polymorphism was associated with several cardiovascular risk factors. ▶ One risk and 3 protective haplotypes for developing ACS were detected.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2010.08.003