Common genetic variants at the CRAC1 ( HMPS ) locus on chromosome 15q13.3 influence colorectal cancer risk

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that incre...

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Veröffentlicht in:	Nature genetics 2008-01, Vol.40 (1), p.26-28
Hauptverfasser:	Tomlinson, Ian, Chandler, Ian, Tenesa, Albert, Farrington, Susan, Domingo, Enric, Martin, Lynn, Vijayakrishnan, Jayaram, Barclay, Ella, Houlston, Richard, Walther, Axel, Wood, Wendy, Gorman, Maggie, Heinimann, Karl, Broderick, Peter, Howarth, Kimberley, Thomas, Huw, Peto, Julian, Campbell, Harry, Webb, Emily, Sullivan, Kate, Penegar, Steven, Papaemmanuil, Elli, Kemp, Zoe, Kerr, David, Gray, Richard, Carvajal-Carmona, Luis, Cazier, Jean-Baptiste, Pittman, Alan, Rowan, Andrew, Lubbe, Steven, Jaeger, Emma, Dunlop, Malcolm, Spain, Sarah, Qureshi, Mobshra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - genetics Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Cell Line, Tumor Cells, Cultured Chromosomes Chromosomes, Human, Pair 15 Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Diagnosis Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Function Genetic aspects Genetic Predisposition to Disease Genetic variance Genetic variation Genetics of eukaryotes. Biological and molecular evolution Health risks Human Genetics Humans Jews - genetics Medical sciences Physiological aspects Polymorphism, Single Nucleotide Population genetics Risk factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Zusammenfassung:	We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 × 10−14).
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng.2007.41