Synaptic vesicles recycling spontaneously and during activity belong to the same vesicle pool

Recently, it has been claimed that vesicles recycling spontaneously and during activity belong to different pools. Here we simultaneously measured, using spectrally separable styryl dyes, the release kinetics of vesicles recycled spontaneously or upon stimulation and the effects of the v-ATPase bloc...

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Veröffentlicht in:	Nature neuroscience 2007-02, Vol.10 (2), p.145-147
Hauptverfasser:	Klingauf, Jurgen, Groemer, Teja W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine brief-communication Cells, Cultured Dyes Electric Stimulation Enzyme Inhibitors - pharmacology Experiments Hippocampus - metabolism Hippocampus - ultrastructure Macrolides - pharmacology Membrane Fusion - drug effects Membrane Fusion - physiology Neural transmission Neurobiology Neurosciences Patch-Clamp Techniques Physiological aspects Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Presynaptic Terminals - ultrastructure Pyridinium Compounds Quaternary Ammonium Compounds Rats Synaptic Membranes - drug effects Synaptic Membranes - metabolism Synaptic Membranes - ultrastructure Synaptic Transmission - drug effects Synaptic Transmission - physiology Synaptic vesicles Synaptic Vesicles - drug effects Synaptic Vesicles - metabolism Synaptic Vesicles - ultrastructure Vacuolar Proton-Translocating ATPases - antagonists & inhibitors Vacuolar Proton-Translocating ATPases - metabolism
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Beschreibung
Zusammenfassung:	Recently, it has been claimed that vesicles recycling spontaneously and during activity belong to different pools. Here we simultaneously measured, using spectrally separable styryl dyes, the release kinetics of vesicles recycled spontaneously or upon stimulation and the effects of the v-ATPase blocker folimycin on the frequency of miniature postsynaptic currents in rat hippocampal neurons. Our results provide evidence as to the identities of the vesicle pools recycling at rest and during stimulation.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn1831