Effect of a serotonin antagonist on delay in grip muscle relaxation for persons with chronic hemiparetic stroke

Highlights ► Our findings support the supposition that monoaminergic brainstem pathways may be disinhibited following stroke. ► Disinhibited monoaminergic brainstem pathways appear to result in increased delays in muscle relaxation. ► Treatments to reduce delay in muscle relaxation may facilitate ha...

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Veröffentlicht in:	Clinical neurophysiology 2011-04, Vol.122 (4), p.796-802
Hauptverfasser:	Seo, Na Jin, Fischer, Heidi W, Bogey, Ross A, Rymer, William Z, Kamper, Derek G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Brain Stem - physiology Cyproheptadine - pharmacology Efferent Pathways - physiology Electrodiagnosis. Electric activity recording Electromyography EMG Female Fingers - physiology Fundamental and applied biological sciences. Psychology Hand - physiology Hand grip Hand Strength - physiology Humans Hyperexcitability Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Motor Neurons - physiology Muscle relaxation Muscle Relaxation - drug effects Nervous system Neurology Paresis - etiology Paresis - physiopathology Serotonin Antagonists - pharmacology Spinal Cord - cytology Spinal Cord - physiology Stroke Stroke - complications Stroke - physiopathology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► Our findings support the supposition that monoaminergic brainstem pathways may be disinhibited following stroke. ► Disinhibited monoaminergic brainstem pathways appear to result in increased delays in muscle relaxation. ► Treatments to reduce delay in muscle relaxation may facilitate hand rehabilitation in persons with stroke.
ISSN:	1388-2457 1872-8952
DOI:	10.1016/j.clinph.2010.10.035