Heterogeneous Postprandial Lipoprotein Responses in the Metabolic Syndrome, and Response to Fenofibrate Therapy

Background Hypertriglyceridemia subjects with metabolic syndrome exhibit variable postprandial triglyceride responses. We investigate the effects of fenofibrate therapy on postprandial triglyceride-containing lipoproteins in subjects with early (3.5 h) versus late (8 h) postprandial triglyceride res...

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Veröffentlicht in:	Cardiovascular drugs and therapy 2010-12, Vol.24 (5-6), p.439-447
Hauptverfasser:	Rosenson, Robert S., Helenowski, Irene B., Tangney, Christine C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiology Cardiovascular system Cholesterol, HDL - blood Cholesterol, LDL - blood Cholesterol, VLDL - blood Double-Blind Method Female Fenofibrate - therapeutic use Humans Hypertriglyceridemia - blood Hypertriglyceridemia - drug therapy Hypolipidemic Agents - therapeutic use Lipoproteins - blood Male Medical sciences Medicine Medicine & Public Health Metabolic diseases Metabolic Syndrome - blood Metabolic Syndrome - drug therapy Middle Aged Miscellaneous Other metabolic disorders Pharmacology. Drug treatments Placebos Postprandial Period - drug effects Triglycerides - blood
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Zusammenfassung:	Background Hypertriglyceridemia subjects with metabolic syndrome exhibit variable postprandial triglyceride responses. We investigate the effects of fenofibrate therapy on postprandial triglyceride-containing lipoproteins in subjects with early (3.5 h) versus late (8 h) postprandial triglyceride responses. Methods Fifty-five subjects with fasting hypertriglyceridemia (≥1.7 mmol/L (150 mg/ dL) and
ISSN:	0920-3206 1573-7241
DOI:	10.1007/s10557-010-6264-6