Cancer stem cells may be mostly maintained by fluctuating hypoxia

Abstract We wonder if most cancer stem cells (CSCs) survive and are maintained in the region of fluctuating hypoxia, which protects them against differentiation. Fluctuating hypoxia, as an important and neglected factor, has been confirmed to induce malignant progression, confer to therapeutic resis...

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Veröffentlicht in:	Medical hypotheses 2011-04, Vol.76 (4), p.471-473
Hauptverfasser:	Sun, Qingjia, Li, Xiaoming, Lu, Xiuying, Di, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Hypoxia Cell Movement Cell Survival Humans Internal Medicine Neoplasms - pathology Neoplastic Stem Cells - pathology Neoplastic Stem Cells - physiology Tumor Microenvironment - physiology
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Zusammenfassung:	Abstract We wonder if most cancer stem cells (CSCs) survive and are maintained in the region of fluctuating hypoxia, which protects them against differentiation. Fluctuating hypoxia, as an important and neglected factor, has been confirmed to induce malignant progression, confer to therapeutic resistance and exist extensively. The subsequent consequence is similar with the behavior of CSCs. Therefore, we cite some examples for our bases and hypothesize CSCs may be mostly maintained by fluctuating hypoxia.
ISSN:	0306-9877 1532-2777
DOI:	10.1016/j.mehy.2010.11.023