Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery

The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. The unique design includes a PEG-sheddable shell and poly(ε-benzyloxycarbonyl-l-lysine) core with a...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2011-03, Vol.47 (12), p.3550-3552
Hauptverfasser:	Wen, Hui-Yun, Dong, Hai-Qing, Xie, Wen-juan, Li, Yong-Yong, Wang, Kang, Pauletti, Giovanni M, Shi, Dong-Lu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Proliferation - drug effects Coated Materials, Biocompatible - chemistry Disulfides - chemistry Doxorubicin - metabolism Doxorubicin - pharmacology Drug Carriers - chemistry Glutathione - chemistry Humans Intracellular Space - metabolism Kinetics Micelles Nanostructures - chemistry Polyethylene Glycols - chemistry Polylysine - analogs & derivatives Polylysine - chemistry
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Beschreibung
Zusammenfassung:	The synthesis and biological efficacy of novel nanomicelles that rapidly disassemble and release their encapsulated payload intracellularly under tumor-relevant glutathione (GSH) levels are reported. The unique design includes a PEG-sheddable shell and poly(ε-benzyloxycarbonyl-l-lysine) core with a redox-sensitive disulfide linkage.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c0cc04983b