Activation of adenosine A2A receptors by polydeoxyribonucleotide increases vascular endothelial growth factor and protects against testicular damage induced by experimental varicocele in rats

In rat experimental varicocele, polydeoxyribonucleotide (PDRN) induces vascular endothelial growth factor (VEGF) production, thereby enhancing testicular function. This may point to a new therapeutic approach in human varicocele.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Fertility and sterility 2011-03, Vol.95 (4), p.1510-1513
Hauptverfasser:	Minutoli, Letteria, M.D, Arena, Salvatore, M.D, Bonvissuto, Giulio, M.D, Bitto, Alessandra, M.D, Polito, Francesca, Ph.D, Irrera, Natasha, Ph.D, Arena, Francesco, M.D, Fragalà, Eugenia, M.D, Romeo, Carmelo, M.D, Nicotina, Piero Antonio, M.D, Fazzari, Carmine, M.D, Marini, Herbert, M.D, Implatini, Alessandra, M.D, Grimaldi, Silvia, M.D, Cantone, Noemi, M.D, Di Benedetto, Vincenzo, M.D, Squadrito, Francesco, M.D, Altavilla, Domenica, Ph.D, Morgia, Giuseppe, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Adenosine A2A-receptor Animals apoptosis Biological and medical sciences Gynecology. Andrology. Obstetrics humans Internal Medicine Male Male genital diseases Medical sciences Non tumoral diseases Obstetrics and Gynecology PDRN Polydeoxyribonucleotides - pharmacology Polydeoxyribonucleotides - therapeutic use Protective Agents - pharmacology Protective Agents - therapeutic use Random Allocation Rats Rats, Sprague-Dawley Receptor, Adenosine A2A - metabolism receptors spermatogenesis Testis - pathology Up-Regulation - physiology varicocele Varicocele - metabolism Varicocele - pathology Varicocele - prevention & control Vascular Endothelial Growth Factor A - biosynthesis vascular endothelial growth factors VEGF
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In rat experimental varicocele, polydeoxyribonucleotide (PDRN) induces vascular endothelial growth factor (VEGF) production, thereby enhancing testicular function. This may point to a new therapeutic approach in human varicocele.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2010.07.1047