An azole-resistant isolate of Malassezia pachydermatis

Canine Malassezia dermatitis (MD) is frequently treated with systemic ketoconazole (KTZ) and itaconazole (ITZ). However, the antifungal susceptibility of clinical isolates of M. pachydermatis from dogs and cats to the azoles has not been well investigated. In the present study, the in vitro suscepti...

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Veröffentlicht in:	Veterinary microbiology 2011-04, Vol.149 (1-2), p.288-290
Hauptverfasser:	Nijima, Misako, Kano, Rui, Nagata, Masahiko, Hasegawa, Atsuhiko, Kamata, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - pharmacology Azole Biological and medical sciences Cats Dogs Drug Resistance, Fungal Drug susceptibility E-test Fundamental and applied biological sciences. Psychology Itraconazole - pharmacology Ketoconazole - pharmacology Malassezia - drug effects Malassezia - isolation & purification Malassezia pachydermatis Microbial Sensitivity Tests Microbiology Miscellaneous Mycology
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Beschreibung
Zusammenfassung:	Canine Malassezia dermatitis (MD) is frequently treated with systemic ketoconazole (KTZ) and itaconazole (ITZ). However, the antifungal susceptibility of clinical isolates of M. pachydermatis from dogs and cats to the azoles has not been well investigated. In the present study, the in vitro susceptibility of the standard strain (CBS1879: the neotype strain of M. pachydermatis) and 29 clinical isolates of M. pachydermatis to the azoles was measured by a modified CLSI M27-A2 test using modified Dixon medium as well as by the E-test. The minimum inhibitory concentrations (MICs) of the 30 isolates of M. pachydermatis (including the neotype strain) against KTZ and ITZ were
ISSN:	0378-1135 1873-2542
DOI:	10.1016/j.vetmic.2010.10.010