Ceramicines E—I, New Limonoids from Chisocheton ceramicus

Five new limonoids, ceramicines E—I (1—5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E—I (1—5) exhibited moderate cell growth inhibitory activities on a range of cell...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2011/03/01, Vol.59(3), pp.407-411
Hauptverfasser:	Wong, Chin Piow, Shimada, Misae, Nagakura, Yuta, Nugroho, Alfarius Eko, Hirasawa, Yusuke, Kaneda, Toshio, Awang, Khalijah, Hadi, A. Hamid A., Mohamad, Khalit, Shiro, Motoo, Morita, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor ceramicine Chisocheton ceramicus Circular Dichroism Crystallography, X-Ray cytotoxic activity Humans Limonins - chemistry Limonins - isolation & purification Limonins - toxicity limonoid Magnetic Resonance Spectroscopy Meliaceae - chemistry Molecular Conformation Plant Bark - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Five new limonoids, ceramicines E—I (1—5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E—I (1—5) exhibited moderate cell growth inhibitory activities on a range of cell lines (HL-60, A549, MCF7, and HCT116). The absolute structure of previously isolated ceramicine B (6) was also elucidated by circular dichroism (CD) and X-ray analysis.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.59.407