Chemical Synthesis and Biological Evaluation of the Englerin Analogues

Improving on nature: The synthesis and biological evaluation of englerin analogues is reported. Structure–activity relationships concerning the cinnamate and glycolic acid domains of englerin A were investigated, revealing insightful information and thereby enabling further diversification of the en...

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Veröffentlicht in:	ChemMedChem 2011-03, Vol.6 (3), p.420-423
Hauptverfasser:	Chan, Kok Ping, Chen, David Y.-K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity antitumor agents Cell Line, Tumor Chemical synthesis cytotoxicity Glycolic acid Humans natural products Phyllanthus - chemistry Sesquiterpenes, Guaiane - chemical synthesis Sesquiterpenes, Guaiane - chemistry Sesquiterpenes, Guaiane - toxicity Structure-Activity Relationship total synthesis
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Beschreibung
Zusammenfassung:	Improving on nature: The synthesis and biological evaluation of englerin analogues is reported. Structure–activity relationships concerning the cinnamate and glycolic acid domains of englerin A were investigated, revealing insightful information and thereby enabling further diversification of the englerin parent structure.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.201000544