Effect of curcumin on JAK-STAT signaling pathway in hepatoma cell lines

The effect of curcumin on JAK-STAT signaling pathway was investigated in hepatoma cell lines Huh7 and Hep3B. Curcumin inhibited cell proliferation and induced apoptosis of both cell lines, but Huh7 cells were more sensitive to curcumin than Hep3B cells. Curcumin (50 micromol x L(-1)) significantly i...

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Veröffentlicht in:	Yao hsüeh hsüeh pao 2009-12, Vol.44 (12), p.1434-1439
Hauptverfasser:	Wang, Wei-Zhang, Zhang, Bi-Yu, Yuan, Jian, Mao, Jian-Wen, Mei, Wen-Jie
Format:	Artikel
Sprache:	chi
Schlagworte:	Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation Curcuma - chemistry Curcumin - isolation & purification Curcumin - pharmacology Humans Janus Kinases - metabolism Liver Neoplasms - metabolism Liver Neoplasms - pathology p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Plants, Medicinal - chemistry Signal Transduction STAT1 Transcription Factor - metabolism
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Zusammenfassung:	The effect of curcumin on JAK-STAT signaling pathway was investigated in hepatoma cell lines Huh7 and Hep3B. Curcumin inhibited cell proliferation and induced apoptosis of both cell lines, but Huh7 cells were more sensitive to curcumin than Hep3B cells. Curcumin (50 micromol x L(-1)) significantly increased phosphorylations of p38 (T180/Y182) and STAT-1 (S727) in Huh7 and Hep3B cells, and caused relocalization of phosphorylated-STAT-1 (Y701) from cytoplasm to nucleus in Hep3B cells. In addition, curcumin (25 and 50 micromol x L(-1)) dramatically suppressed the phosphorylation level of STAT-1 (Y701) and resulted in a significant reduction of nuclear phosphorylated-STAT-1 (Y701) in Huh7 cells.
ISSN:	0513-4870