A Convergent Synthesis of the C1−C16 Segment of Goniodomin A via Palladium-Catalyzed Organostannane−Thioester Coupling

A Convergent Synthesis of the C1−C16 Segment of Goniodomin A via Palladium-Catalyzed Organostannane−Thioester Coupling

A convergent synthesis of the C1−C16 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved via a 2-fold application of palladium-catalyzed organostannane−thioester coupling.

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Veröffentlicht in:Organic letters 2011-03, Vol.13 (5), p.1106-1109
Hauptverfasser: Fuwa, Haruhiko, Nakajima, Motohiro, Shi, Jinglu, Takeda, Yoshiyuki, Saito, Tomoyuki, Sasaki, Makoto
Format: Artikel
Sprache:eng
Schlagworte:
Actins - metabolism
Catalysis
Esters
Ethers - chemical synthesis
Ethers - chemistry
Ethers - pharmacology
Macrolides - chemical synthesis
Macrolides - chemistry
Macrolides - pharmacology
Molecular Structure
Organotin Compounds - chemistry
Palladium - chemistry
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Beschreibung
Zusammenfassung:A convergent synthesis of the C1−C16 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved via a 2-fold application of palladium-catalyzed organostannane−thioester coupling.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1031409