Phorbasones A and B, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp. and Induction of Osteoblast Differentiation

Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2011-03, Vol.13 (5), p.884-887
Hauptverfasser: Rho, Jung-Rae, Hwang, Buyng Su, Joung, Seewon, Byun, Mi Ran, Hong, Jeong-Ho, Lee, Hee-Yoon
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol1029386