Phorbasones A and B, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp. and Induction of Osteoblast Differentiation
Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogen...
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Veröffentlicht in: | Organic letters 2011-03, Vol.13 (5), p.884-887 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Two new sesterterpenoids, phorbasones A (1) and B (2), were isolated from the Korean marine sponge Phorbas sp. Their complete structures were elucidated by spectral data and chemical reactions. Phorbasone A exhibited a positive effect on the calcium deposition activity in C3H10T1/2 cells. The biogenic origin of the core structure is believed to be through a novel rearrangement from the ansellone carbon structure. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol1029386 |