Autoxidative Annulation Cascade of the α-Cyano β-TMS-capped Alkynyl Cycloalkanone System

The autoxidative annulation cascade promoted by an α-cyano β-TMS-capped alkynyl cycloalkanone system under catalysis with pyridine in one oxygen atmosphere has proven to be highly viable. On the basis of this newly developed protocol, a variety of highly functionalized bicyclic frameworks can be eff...

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Veröffentlicht in:	Organic letters 2011-03, Vol.13 (5), p.896-899
Hauptverfasser:	Wong, Ying-Chieh, Hsieh, Min-Tsang, Amancha, Prashanth K, Chin, Chih-Lung, Liao, Cheng-Feng, Kuo, Chun-Wei, Shia, Kak-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Combinatorial Chemistry Techniques Ketones - chemical synthesis Ketones - chemistry Molecular Structure Nitriles - chemical synthesis Nitriles - chemistry Pyridines - chemistry Stereoisomerism Trimethylsilyl Compounds - chemical synthesis Trimethylsilyl Compounds - chemistry
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Beschreibung
Zusammenfassung:	The autoxidative annulation cascade promoted by an α-cyano β-TMS-capped alkynyl cycloalkanone system under catalysis with pyridine in one oxygen atmosphere has proven to be highly viable. On the basis of this newly developed protocol, a variety of highly functionalized bicyclic frameworks can be effectively constructed.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol102947u