The Clinical Relevance of Chromogranin A as a Biomarker for Gastroenteropancreatic Neuroendocrine Tumors

Chromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of gastroenteropancreatic neuroendocrine tumors (NETs). The value of the chromogranin A lies in its universal cosecretion by the majority of neuroe...

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Veröffentlicht in:	Endocrinology and metabolism clinics of North America 2011-03, Vol.40 (1), p.111-134
Hauptverfasser:	Lawrence, Ben, MBChB, MSc, Gustafsson, Bjorn I., MD, PhD, Kidd, Mark, PhD, Pavel, Marianne, MD, Svejda, Bernhard, MD, Modlin, Irvin M., MD, PhD, DSc, FRCS(Eng & Ed)
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - analysis Biomarkers, Tumor - blood Biomarkers, Tumor - metabolism Biomarkers, Tumor - physiology Chromogranin A - analysis Chromogranin A - blood Chromogranin A - metabolism Chromogranin A - physiology Diagnostic Techniques, Endocrine - standards Endocrinology & Metabolism Gastrointestinal Neoplasms - blood Gastrointestinal Neoplasms - diagnosis Gastrointestinal Neoplasms - metabolism Humans Models, Biological Neuroendocrine Cells - metabolism Neuroendocrine Cells - pathology Neuroendocrine Tumors - blood Neuroendocrine Tumors - diagnosis Neuroendocrine Tumors - metabolism Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - metabolism Predictive Value of Tests
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Beschreibung
Zusammenfassung:	Chromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of gastroenteropancreatic neuroendocrine tumors (NETs). The value of the chromogranin A lies in its universal cosecretion by the majority of neuroendocrine cells that persists after malignant transformation. Clinicians aware of the physiologic role of chromogranin A and its secretion in a variety of non-NET–related pathologic conditions can use this protein as a moderately effective tumor biomarker in the management of GEP-NETs.
ISSN:	0889-8529 1558-4410
DOI:	10.1016/j.ecl.2010.12.001