Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis

Generation gap: Three generations of process research and development towards the industrial manufacture of sitagliptin phosphate (1), a leading drug for type 2 diabetes, are highlighted.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2011-02, Vol.50 (9), p.1974-1976
1. Verfasser: Desai, Aman A
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
Biocatalysis
Catalysis
Diabetes Mellitus, Type 2 - drug therapy
Green chemistry
Green Chemistry Technology
Humans
process chemistry
Pyrazines - chemical synthesis
Pyrazines - chemistry
Pyrazines - therapeutic use
Ruthenium - chemistry
sitagliptin
Sitagliptin Phosphate
Transaminases - metabolism
Triazoles - chemical synthesis
Triazoles - chemistry
Triazoles - therapeutic use
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Beschreibung
Zusammenfassung:Generation gap: Three generations of process research and development towards the industrial manufacture of sitagliptin phosphate (1), a leading drug for type 2 diabetes, are highlighted.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201007051