Effects of feed-borne Fusarium mycotoxins and an organic mycotoxin adsorbent on immune cell dynamics in the jejunum of chickens infected with Eimeria maxima
An experiment was conducted to explore the effects of Fusarium mycotoxins, common animal feed contaminants, on intestinal immune responses to coccidia ( Eimeria) in chickens. Effects of feed-borne Fusarium mycotoxins and a polymeric glucomannan mycotoxin adsorbent (GMA) on immune cell populations we...
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Veröffentlicht in: | Veterinary immunology and immunopathology 2010-12, Vol.138 (3), p.218-223 |
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Zusammenfassung: | An experiment was conducted to explore the effects of
Fusarium mycotoxins, common animal feed contaminants, on intestinal immune responses to coccidia (
Eimeria) in chickens. Effects of feed-borne
Fusarium mycotoxins and a polymeric glucomannan mycotoxin adsorbent (GMA) on immune cell populations were studied in the jejunum of broiler breeder pullets using an
Eimeria maxima infection model. Birds were fed a control diet, a diet naturally contaminated with
Fusarium mycotoxins, contaminated diet plus 0.2% GMA, or control diet plus 0.2% GMA. Contaminated diets contained up to 6.5
μg/g deoxynivalenol (DON), 0.47
μg/g 15-acetyl-DON and 0.73
μg/g zearalenone. Birds received a primary oral inoculation (1000
oocysts/bird) with
E. maxima USDA strain 68 at 2 weeks of age and a secondary oral inoculation (30,000
oocysts/bird) with the same strain at 4 weeks of age. Diet-related differences in CD4
+ cell, CD8
+ cell and macrophage recruitment pattern into the jejunum were observed following both the primary and secondary infections. It was concluded that feed-borne
Fusarium mycotoxins and GMA have the potential to modulate immune response to coccidial infections. |
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ISSN: | 0165-2427 1873-2534 |
DOI: | 10.1016/j.vetimm.2010.07.018 |