In situ molecular detection of ischemic cells by enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm

In situ molecular detection of ischemic cells by enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm

To overcome shortcomings of the ex situ approaches, in situ detection using H(2)O(2) molecules to diagnose ischemia through enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm is demonstrated and it is discovered that the extrac...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-03, Vol.47 (9), p.2652-2654
Hauptverfasser: Guo, Chun Xian, Zheng, Xin Ting, Ng, Shu Rui, Lai, Yicheng, Lei, Yu, Li, Chang Ming
Format: Artikel
Sprache:eng
Schlagworte:
Aniline Compounds - chemistry
Animals
Biosensing Techniques - methods
Catalase - metabolism
Electrochemical Techniques
Electrodes
Electron Transport
Gold - chemistry
Horseradish Peroxidase - chemistry
Horseradish Peroxidase - metabolism
Hydrogen Peroxide - analysis
Metal Nanoparticles - chemistry
Myocytes, Smooth Muscle - cytology
Myocytes, Smooth Muscle - metabolism
Nanowires - chemistry
Nanowires - ultrastructure
Oxidation-Reduction
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Zusammenfassung:To overcome shortcomings of the ex situ approaches, in situ detection using H(2)O(2) molecules to diagnose ischemia through enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm is demonstrated and it is discovered that the extracellular H(2)O(2) molecule released per ischemic cell is 2.7-times of that of a normal cell.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc04542j