Actions of a coral toxin analogue (Bipinnatin-B) on an insect nicotinic acetylcholine receptor

The lophotoxin analogue, bipinnatin-B, is a potent neurotoxin isolated from the gorgonian coral Pseudopterogorgia bipinnata. When tested on the cell body of an identified motor neurone, the fast coxal depressor motor neurone (Df) in the cockroach metathoracic ganglion, bipinnatin-B, at concentration...

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Veröffentlicht in:Archives of insect biochemistry and physiology 1993, Vol.23 (4), p.155-159
Hauptverfasser: Bai, D, Abramson, S.N, Sattelle, D.B
Format: Artikel
Sprache:eng
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Zusammenfassung:The lophotoxin analogue, bipinnatin-B, is a potent neurotoxin isolated from the gorgonian coral Pseudopterogorgia bipinnata. When tested on the cell body of an identified motor neurone, the fast coxal depressor motor neurone (Df) in the cockroach metathoracic ganglion, bipinnatin-B, at concentrations of 10 micromolar, partially blocked nicotine-induced depolarization. Blockade of the response to nicotine was almost complete at 30 micromolar bipinnatin-B, and was partially reversible on rebathing the preparation in normal saline. Responses of the same neurone to GABA were unaffected by 30 micromolar bipinnatin-B
ISSN:0739-4462
1520-6327
DOI:10.1002/arch.940230402