Total Synthesis of Broussonetine F: The Orthoamide Overman Rearrangement of an Allylic Diol
A first total synthesis of broussonetine F from diethyl l-tartrate was achieved. The cornerstone of our synthesis was an orthoamide Overman rearrangement, which provided an allylic amino alcohol with complete diastereoselectivity.
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Veröffentlicht in: | Organic letters 2011-02, Vol.13 (4), p.616-619 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A first total synthesis of broussonetine F from diethyl l-tartrate was achieved. The cornerstone of our synthesis was an orthoamide Overman rearrangement, which provided an allylic amino alcohol with complete diastereoselectivity. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol102856j |