PULMONARY ASPERGILLOSIS CAUSED BY A PAN-AZOLE-RESISTANT ASPERGILLUS FUMIGATUS IN A 10-YEAR-OLD BOY

A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposom...

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Veröffentlicht in:	The Pediatric infectious disease journal 2011-03, Vol.30 (3), p.268-270
Hauptverfasser:	Thors, Valtyr S, Bierings, Marc B, Melchers, Willem J. G, Verweij, Paul E, Wolfs, Tom F. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphotericin B - administration & dosage Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - pharmacology Aspergillus fumigatus - drug effects Aspergillus fumigatus - isolation & purification Azoles - administration & dosage Azoles - pharmacology Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Chemoprevention - methods Child Drug Resistance, Multiple, Fungal Hematopoietic Stem Cell Transplantation Human mycoses Humans Infectious diseases Male Medical sciences Mycoses Mycoses of the respiratory system Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Pulmonary Aspergillosis - diagnosis Pulmonary Aspergillosis - drug therapy Pulmonary Aspergillosis - microbiology Pyrimidines - administration & dosage Transfusions. Complications. Transfusion reactions. Cell and gene therapy Treatment Outcome Triazoles - administration & dosage Voriconazole
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Beschreibung
Zusammenfassung:	A 10-year-old boy with high-risk acute lymphoblastic leukemia treated with hematopoietic stem-cell transplantation developed pulmonary aspergillosis while receiving prophylactic voriconazole. A transpleural aspirate culture revealed a pan-azole-resistant Aspergillus fumigatus. Treatment with liposomal amphotericin B resulted in complete recovery. As the frequency of azole resistance in A. fumigatus increases, invasive procedures to isolate fungi for species identification and susceptibility testing becomes even more important.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0b013e3182037879