Thrombocytopenia and anemia caused by a persistent high linezolid concentration in patients with renal dysfunction

Abstract It has been proposed that it is not necessary to adjust the dose of linezolid (LZD) in patients with reduced renal function. However, significantly lower platelet counts and hemoglobin levels have been reported in such patients compared to those in patients with normal renal function. This suggests that the appropriate dose and administration method for LZD are yet to be established in patients with renal dysfunction. The subjects in this study were patients with renal dysfunction who developed adverse effects of thrombocytopenia and anemia during treatment with LZD. We investigated the association of these adverse effects with the blood LZD concentration and the area under the concentration–time curve from zero to 24 h (AUC0–24 ), determined using a one-compartment Bayesian model ( n = 20). The measured blood LZD concentration was significantly higher than the predicted concentration in a population pharmacokinetics approach ( p