Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam₃CysSer

More sugar with your “T”: The title candidates comprising per‐glycosylated MUC1 peptides, a T‐cell helper peptide, and an immunoadjuvant were assembled in high yields using iterative pentafluorophenyl ester‐mediated fragment condensations. Following immunological evaluation, a tricomponent vaccine bearing clustered glycosylation with the T‐antigen was identified (see structure) which elicited high IgG antibody titers in murine models without an external adjuvant.