DNA microarray analysis of the liver of mice treated with cobalt chloride

To investigate the in vivo effects of cobalt chloride on gene expression at early time points, DNA microarray analysis was performed on the liver of mice injected subcutaneously with cobalt chloride. The liver tissue samples were taken 0.5, 1, and 3 hr after injection. Of the 14 genes up-regulated a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of toxicological sciences 2010/12/01, Vol.35(6), pp.935-939
Hauptverfasser:	Matsumoto, Kanako, Fujishiro, Hitomi, Satoh, Masahiko, Himeno, Seiichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cobalt Cobalt - toxicity DNA microarray DNA, Complementary - genetics Gene Expression - drug effects Gene Expression Profiling Liver Liver - drug effects Liver - metabolism Liver - pathology Male Mice Mice, Inbred ICR Mouse Oligonucleotide Array Sequence Analysis RNA - genetics RNA, Complementary - genetics Toxicity Tests
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To investigate the in vivo effects of cobalt chloride on gene expression at early time points, DNA microarray analysis was performed on the liver of mice injected subcutaneously with cobalt chloride. The liver tissue samples were taken 0.5, 1, and 3 hr after injection. Of the 14 genes up-regulated at 0.5 hr after injection, 7 are related to immunological responses, and 4 of the 7 were found to be involved in the activation of interferon.
ISSN:	0388-1350 1880-3989 1880-3989
DOI:	10.2131/jts.35.935