Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury

Overwhelming evidence suggests that ischemia-reperfusion injury of the kidney is an inflammatory disease mediated by innate and adoptive immune systems. The neuronal guidance molecule netrin-1 was shown to modulate inflammatory responses. Given that ischemic kidney is particularly prone to reperfusi...

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Veröffentlicht in:	The Journal of immunology (1950) 2010-09, Vol.185 (6), p.3750-3758
Hauptverfasser:	Tadagavadi, Raghu Kempegowda, Wang, Weiwei, Ramesh, Ganesan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Inflammation Mediators - physiology Interleukin-17 - biosynthesis Kidney Diseases - immunology Kidney Diseases - pathology Kidney Diseases - physiopathology Kidney Diseases - prevention & control Kidney Function Tests Male Mice Mice, Inbred C57BL Nerve Growth Factors - physiology Netrin Receptors Netrin-1 Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - physiology Reperfusion Injury - immunology Reperfusion Injury - pathology Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - pathology Th2 Cells - immunology Th2 Cells - metabolism Th2 Cells - pathology Tumor Suppressor Proteins - physiology
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